The Mcm2-Ctf4-Pol? Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands (Molecular Cell)

How parental histone H3-H4 tetramers are transferred to replicating DNA strands for epigenetic inheritance remains largely unknown. Gan et al. show that parental H3-H4 tetramers bind to Mcm2, which travels along the leading-strand template, and are then transferred to the lagging strand by the Mcm2-Ctf4-Pol? complex for nucleosome assembly.