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RSS FeedsMaintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans (Cell Reports)

 
 

4 october 2018 21:02:43

 
Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans (Cell Reports)
 


Rieckher et al. uncover a mechanism modulating protein synthesis during aging in the Caenorhabditis elegans soma, through association of the mRNA translation initiation factor eIF4E with mRNA processing (P) bodies (PBs). Effects on longevity are mediated by attenuation of global protein synthesis in somatic tissues via the sequestration of eIF4E in PBs.


 
163 viewsCategory: Cell Biology
 
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