Single-Molecule Analysis Reveals Linked Cycles of RSC Chromatin Remodeling and Ace1p Transcription Factor Binding in Yeast (Molecular Cell)

In this study, Mehta et al. show that rapid cycles of the yeast transcription factor Ace1p at CUP1 promoter serve as a pace-maker for the transcription bursts. The chromatin remodeler RSC fine-tunes this cycle by short repetitive cycles of nucleosome mobilization.