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13 october 2018 00:00:15

 
Spt6 Is Required for the Fidelity of Promoter Selection (Molecular Cell)
 


Doris et al. show that Spt6, a conserved transcription factor, is broadly required for the accuracy of transcription initiation by RNA polymerase II. In the absence of Spt6, transcription initiates at thousands of new sites, likely due to the presence of specific sequence features along with changes in chromatin structure.


 
170 viewsCategory: Molecular Biology, Cell Biology
 
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