A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival (Molecular Cell)

Yap et al. show that several short tandem repeats (STRs) encoded in the human genome are transcribed at a readily detectable level. The STR-enriched RNA PNCTR sequesters multiple copies of PTBP1 in the perinucleolar compartment, thus modulating splicing regulation function of this RNA-binding protein and promoting cancer cell survival.