MyJournals Home  

RSS FeedsIJMS, Vol. 19, Pages 3155: BDNF, Brain, and Regeneration: Insights from Zebrafish (International Journal of Molecular Sciences)


13 october 2018 16:00:27

IJMS, Vol. 19, Pages 3155: BDNF, Brain, and Regeneration: Insights from Zebrafish (International Journal of Molecular Sciences)

Zebrafish (Danio rerio) is a teleost fish widely accepted as a model organism for neuroscientific studies. The adults show common basic vertebrate brain structures, together with similar key neuroanatomical and neurochemical pathways of relevance to human diseases. However, the brain of adult zebrafish possesses, differently from mammals, intense neurogenic activity, which can be correlated with high regenerative properties. Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family, has multiple roles in the brain, due also to the existence of several biologically active isoforms, that interact with different types of receptors. BDNF is well conserved in the vertebrate evolution, with the primary amino acid sequences of zebrafish and human BDNF being 91% identical. Here, we review the available literature regarding BDNF in the vertebrate brain and the potential involvement of BDNF in telencephalic regeneration after injury, with particular emphasis to the zebrafish. Finally, we highlight the potential of the zebrafish brain as a valuable model to add new insights on future BDNF studies. Digg Facebook Google StumbleUpon Twitter
22 viewsCategory: Biochemistry, Biophysics, Molecular Biology
IJMS, Vol. 19, Pages 3156: PEG-Plasma Hydrogels Increase Epithelialization Using a Human Ex Vivo Skin Model (International Journal of Molecular Sciences)
IJMS, Vol. 19, Pages 3154: Relationship between the Regulation of Caspase-8-Mediated Apoptosis and Radioresistance in Human THP-1-Derived Macrophages (International Journal of Molecular Sciences)
blog comments powered by Disqus
The latest issues of all your favorite science journals on one page


Register | Retrieve


Molecular Biology

Use these buttons to bookmark us: Digg Facebook Google StumbleUpon Twitter

Valid HTML 4.01 Transitional
Copyright © 2008 - 2019 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Travel Photos Nachrichten Indigonet Finances Leer Mandarijn