The purpose of this research was to improve the performance of a wireless body area sensor network, operating on a person in the seated and standing positions. Optimization-focused on both the on-body transmission channel and off-body link performance. The system consists of three nodes. One node (on the user’s head) is fixed, while the positions of the other two (one on the user’s trunk and the other on one leg) with respect to the body (local coordinates) are design variables. The objective function used in the design process is characterized by two components: the first controls the wireless channel for on-body data transmission between the three sensor nodes, while the second controls the off-body transmission between the nodes and a remote transceiver. The optimal design procedure exploits a low-cost Estra, which is an evolutionary strategy optimization algorithm linked with Remcom XFdtd, a full-wave Finite-Difference Time-Domain (FDTD) electromagnetic field analysis package. The Pareto-like approach applied in this study searches for a non-dominated solution that gives the best compromise between on-body and off-body performance.