Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity (Cell Reports)

Timper et al. show that mild impairment of mitochondrial OXPHOS upon deletion of AIF or MPC1 in hypothalamic POMC-expressing neurons increases their fatty acid utilization and ROS formation, prevents obesity-induced silencing of these neurons, and improves systemic glucose metabolism in obesity.