Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans (Cell Reports)

In a comparative metabolic screen of rodents and humans, Walters et al. show that circulating sarcosine is similarly reduced with aging and increased by dietary restriction. They demonstrate that sarcosine activates macroautophagy in cultured cells and in vivo, suggesting a role in improved proteostasis via dietary restriction.