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RSS FeedsDefective Mitochondrial Cardiolipin Remodeling Dampens HIF-1? Expression in Hypoxia (Cell Reports)

 
 

18 october 2018 10:00:11

 
Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1? Expression in Hypoxia (Cell Reports)
 


Defective remodeling of the mitochondrial phospholipid cardiolipin causes cardiomyopathy in Barth syndrome patients. Chowdhury et al. show that dysfunctional mitochondria affect the HIF-1? response to hypoxia. They demonstrate that mitochondrial ROS is required for NF-?B-mediated gene induction of HIF-1?.


 
61 viewsCategory: Cell Biology
 
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