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RSS FeedsMolecules, Vol. 23, Pages 2663: Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer`s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory Loss (Molecules)

 
 

18 october 2018 13:00:02

 
Molecules, Vol. 23, Pages 2663: Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer`s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory Loss (Molecules)
 


Gx-50 is a bioactive compound for the treatment of Alzheimer’s disease (AD) found in Sichuan pepper (Zanthoxylum bungeanum). In order to find a stronger anti-AD lead compound, 20 gx-50 (1–20) analogs have been designed and synthesized, and their molecular structures were determined based on nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis, as well as comparison with literature data. Compounds 1–20 were evaluated for their anti-AD potential by using DPPH radical scavenging assay for considering their anti-oxidant activity, thioflavin T (ThT) fluorescence assay for considering the inhibitory or disaggregate potency of Aβ, and transgenic Drosophila model assay for evaluating their rescue effect on memory loss. Finally, compound 13 was determined as a promising anti-AD candidate.


 
75 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
Molecules, Vol. 23, Pages 2664: Lignocellulosic Biomass as Source for Lignin-Based Environmentally Benign Antioxidants (Molecules)
Molecules, Vol. 23, Pages 2661: Chitosan-Based Nanomaterials for Drug Delivery (Molecules)
 
 
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