A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila (Cell Metabolism)

Scopelliti et al. identified a novel intestinal/neuronal/adipose tissue communication network in Drosophila with implications for endocrine-regulated metabolic homeostasis. In response to nutrients, enteroendocrine cells (EE) secrete the neuroendocrine peptide Bursicon ?, which binds to its neuronal receptor DLgr2 to regulate organismal resistance to metabolic challenges through adipose glucagon-like AKHR signaling.