Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation (Molecular Cell)

Weith et al. demonstrate that newly synthesized PP1 is first held in an inactive complex by SDS22 and inhibitor-3 that needs to be disassembled by the p97 AAA-ATPase to promote exchange to substrate specifiers. Disassembly involves direct interaction of the p37 adapter with inhibitor-3, followed by its ATP-driven unfolding.