CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress (Molecular Cell)

Przetocka et al. identify a function of CtIP in maintaining replication fork stability that is distinct from its role in DSB resection. CtIP keeps DNA2 nuclease in check to limit the degradation of stalled forks. Loss of CtIP in BRCA1-deficient cells aggravates replication-stress-induced genomic instability, causing synthetic lethality.