The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage (Molecular Cell)

Histone variants convey epigenetic information and define functional chromatin states. Piquet et al. describe a reshaping of histone variant patterns at sites of UVC damage repair with H2A.Z removal followed by de novo deposition of H2A.X. The H2A.X deposition machinery provides a means for fine-tuning DNA damage signaling.