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RSS FeedsB Cell Receptor Crosslinking Augments Germinal Center B Cell Selection when T Cell Help Is Limiting (Cell Reports)

 
 

7 november 2018 07:00:26

 
B Cell Receptor Crosslinking Augments Germinal Center B Cell Selection when T Cell Help Is Limiting (Cell Reports)
 




Turner et al. show that recurrent antigen-dependent BCR crosslinking is not required for GC centrocytes selection and differentiation into plasmablasts in vivo. However, when T cell help is subsaturating, BCR signaling can synergize with follicular T cell help to potentiate GC B cell selection and their differentiation into plasmablasts.


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32 viewsCategory: Cell Biology
 
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