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RSS FeedsIJMS, Vol. 19, Pages 3503: NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple Myeloma (International Journal of Molecular Sciences)

 
 

8 november 2018 02:00:03

 
IJMS, Vol. 19, Pages 3503: NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple Myeloma (International Journal of Molecular Sciences)
 




Multiple myeloma with clonal plasma expansion in bone marrow is the second most common hematologic malignancy in the world. Though the improvement of outcomes from the achievement of novel agents in recent decades, the disease progresses and leads to death eventually due to the elusive nature of myeloma cells and resistance mechanisms to therapeutic agents. In addition to the molecular and genetic basis of resistance pathomechanisms, the bone marrow microenvironment also contributes to disease progression and confers drug resistance in myeloma cells. In this review, we focus on the current state of the literature in terms of critical bone marrow microenvironment components, including soluble factors, cell adhesion mechanisms, and other cellular components. Transcriptional factor nuclear factor erythroid-derived-2-like 2 (NRF2), a central regulator for anti-oxidative stresses and detoxification, is implicated in chemoresistance in several cancers. The functional roles of NRF2 in myeloid-derived suppressor cells and multiple myeloma cells, and the potential of targeting NRF2 for overcoming microenvironment-mediated drug resistance in multiple myeloma are also discussed.


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71 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 19, Pages 3504: Pediococcus pentosaceus-Fermented Cordyceps militaris Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis (International Journal of Molecular Sciences)
IJMS, Vol. 19, Pages 3502: Insights into Tear Film Stability from Babies and Young Adults: A Study of Human Meibum Lipid Conformation and Rheology (International Journal of Molecular Sciences)
 
 
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