Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models (Cell Metabolism)

AMPK can either inhibit or promote tumor growth depending on tumor type and context. Eichner et al. show that AMPK, unlike LKB1, has a pro-tumorigenic role in a Kras-dependent, non-small-cell lung cancer model through the regulation of Tfe3, a master regulator of lysosomes, which supports lung tumor growth.