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RSS FeedsSpatiotemporal m(i)RNA Architecture and 3´ UTR Regulation in the C. elegans Germline (Developmental Cell)

 
 

10 november 2018 06:00:31

 
Spatiotemporal m(i)RNA Architecture and 3´ UTR Regulation in the C. elegans Germline (Developmental Cell)
 




Diag and Schilling et al. present a near single-cell gonad map of mRNAs and miRNAs and previously unannotated miRNAs and 3´ UTRs. By mutant analysis, regulators and mechanisms explaining highly dynamic spatiotemporal changes of 3´ UTR isoforms were identified. A mathematical, interrogable 3D gonad model allows comprehensive resolution of mRNA and miRNA expression in time (min) and space (~1-100 cells).


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36 viewsCategory: Cell Biology
 
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