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RSS FeedsMarine Drugs, Vol. 16, Pages 436: Ishophloroglucin A, a Novel Phlorotannin for Standardizing the Anti-?-Glucosidase Activity of Ishige okamurae (Marine Drugs)

 
 

10 november 2018 12:01:31

 
Marine Drugs, Vol. 16, Pages 436: Ishophloroglucin A, a Novel Phlorotannin for Standardizing the Anti-?-Glucosidase Activity of Ishige okamurae (Marine Drugs)
 




Nutraceutical use of algae requires understanding of the diversity and significance of their active compositions for intended activities. Ishige okamurae (I. okamurae) extract is well-known to possess α-glucosidase inhibitory activity; however, studies are needed to investigate its active composition in order to standardize its α-glucosidase inhibitory activity. In this study, we observed the intensity of the dominant compounds of each I. okamurae extract harvested between 2016 and 2017, and the different potency of each I. okamurae extract against α-glucosidase. By comparing the anti-α-glucosidase ability of the dominant compounds, a novel Ishophloroglucin A with highest α-glucosidase inhibitory activity was identified and suggested for standardization of anti-α-glucosidase activity in I. okamurae extract. Additionally, a validated analytical method for measurement of Ishophloroglucin A for future standardization of I. okamurae extract was established in this study. We suggest using Ishophloroglucin A to standardize anti-α-glucosidase potency of I. okamurae and propose the significance of standardization based on their composition for effective use of algae as marine-derived nutraceuticals.


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36 viewsCategory: Biochemistry, Molecular Biology, Pharmacology
 
Marine Drugs, Vol. 16, Pages 437: 6-Bromoindole Derivatives from the Icelandic Marine Sponge Geodia barretti: Isolation and Anti-Inflammatory Activity (Marine Drugs)
Marine Drugs, Vol. 16, Pages 444: Novel Bioactive Peptides from Meretrix meretrix Protect Caenorhabditis elegans against Free Radical-Induced Oxidative Stress through the Stress Response Factor DAF-16/FOXO (Marine Drugs)
 
 
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