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RSS FeedsViruses, Vol. 10, Pages 614: The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts (Viruses)


10 november 2018 13:00:02

Viruses, Vol. 10, Pages 614: The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts (Viruses)

Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus for which there is no vaccine or cure. This viral infection, once acquired, is life-long, residing latently in hematopoietic cells. However, latently infected individuals with weakened immune systems often undergo HCMV reactivation, which can cause serious complications in immunosuppressed and immunocompromised patients. Current anti-viral therapies target late stages of viral replication, and are often met with therapeutic resistance, necessitating the development of novel therapeutics. In this current study, we identified a naturally-occurring flavonoid compound, deguelin, which inhibits HCMV lytic replication. Our findings reveal that nanomolar concentrations of deguelin significantly suppress the production of the infectious virus. Further, we show that deguelin inhibits the lytic cycle during the phase of the replication cycle consistent with early (E) gene and protein expression. Importantly, our data reveal that deguelin inhibits replication of a ganciclovir-resistant strain of HCMV. Together, our findings identify a novel, naturally occurring compound that may prove useful in the treatment of HCMV replication. Digg Facebook Google StumbleUpon Twitter
56 viewsCategory: Epidemiology, Virology
Viruses, Vol. 10, Pages 615: Persistence and Intra-Host Genetic Evolution of Zika Virus Infection in Symptomatic Adults: A Special View in the Male Reproductive System (Viruses)
Viruses, Vol. 10, Pages 613: Meeting Review: 2018 International Workshop on Structure and Function of the Lentiviral gp41 Cytoplasmic Tail (Viruses)
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