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RSS FeedsDefining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1 (Structure)

 
 

10 november 2018 15:00:23

 
Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1 (Structure)
 




The orphan nuclear receptor Nurr1 is thought to lack a canonical ligand-binding pocket for natural ligands. Solution structural analyses of the Nurr1 ligand-binding domain (LBD) show that its putative ligand-binding pocket is dynamic, solvent accessible, and expands to bind unsaturated fatty acids.


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16 viewsCategory: Biochemistry
 
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