Sampling Native-like Structures of RNA-Protein Complexes through Rosetta Folding and Docking (Structure)

RNA and protein molecules interact intimately during ribosome translation, pre-mRNA splicing, and other fundamental cellular processes. Structures of the relevant RNA-protein complexes often elude high-resolution determination. Kappel and Das report a computational Rosetta method RNP-denovo that can incorporate sparse experimental data and sample native-like structures of RNA-protein complexes.