RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T Helper 2 Cell-Biased Programs (Immunity)

Pathogenic Th17 cells promote immune pathology, but how their generation is controlled remains largely unknown. Wu et al. reveal that RASA3 is essential for pathogenic Th17 cell generation but dispensable for non-pathogenic Th17 cell generation. RASA3 functions by repressing Th2 cell programs in pathogenic Th17 cells by fine-tuning IRF4 protein expression.