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RSS FeedsOncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype (Cell Stem Cell)

 
 

16 november 2018 12:00:15

 
Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype (Cell Stem Cell)
 


Kim and colleagues show that tissue regeneration elicits formation of tumors originating from adult stem cells. Purification of tumor cells enabled identification of oncogenic drivers, including Duxbl, that are normally expressed in early zygotes. Dux factors initiate tumorigenesis through an MET-like transition and define a broad range of human cancers.


 
108 viewsCategory: Cell Biology
 
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Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics (Cell Stem Cell)
 
 
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