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RSS FeedsIJMS, Vol. 19, Pages 3880: The Interleukin-17 Family of Cytokines in Breast Cancer (International Journal of Molecular Sciences)

 
 

5 december 2018 02:00:12

 
IJMS, Vol. 19, Pages 3880: The Interleukin-17 Family of Cytokines in Breast Cancer (International Journal of Molecular Sciences)
 




Breast cancer (BC) is the most common cancer in women worldwide and remains a major cause of mortality with an expected 137,000 death this year in Europe. Standard management of metastatic BC comprises hormonotherapy, chemotherapy, and targeted therapies. Cyclin dependent kinase (CDK) and mammalian target of rapamycin (mTOR) inhibitors have recently proved their efficiency in hormonal receptor expressing BC. Checkpoint proteins inhibition is being evaluated in phase 3 studies. Since inflammation is constantly present in cancers, research teams have focused their attention on the interleukin-17 (IL-17) family of proinflammatory cytokines. Preclinical experiments have reported both pro and antitumor effects depending on the conditions. In the present article, we review the accumulating evidences about the roles of IL-17 in BC and discuss whether this family of cytokines could be a new target in anticancer treatments.


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21 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 19, Pages 3881: Tissue-Specific Down-Regulation of the Long Non-Coding RNAs PCAT18 and LINC01133 in Gastric Cancer Development (International Journal of Molecular Sciences)
IJMS, Vol. 19, Pages 3879: Genetic Polymorphisms Associated with Spontaneous Intracerebral Hemorrhage (International Journal of Molecular Sciences)
 
 
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