The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex (Cell Metabolism)

Although it is known that mTORC1 oscillates in a circadian fashion, the underlying mechanisms are unclear. Wu et al. show that Per2, a core clock protein, is induced by glucagon-Creb/Crtc2 signaling and acts as a scaffold to tether Tsc1 and mTOR together and to suppress liver mTORC1 activity during fasting.