MyJournals Home  

RSS FeedsMolecules, Vol. 23, Pages 3223: DDQ-Promoted Mild and Efficient Metal-Free Oxidative ?-Cyanation of N-Acyl/Sulfonyl 1,2,3,4-Tetrahydroisoquinolines (Molecules)

 
 

8 december 2018 19:00:24

 
Molecules, Vol. 23, Pages 3223: DDQ-Promoted Mild and Efficient Metal-Free Oxidative ?-Cyanation of N-Acyl/Sulfonyl 1,2,3,4-Tetrahydroisoquinolines (Molecules)
 




A mild and highly efficient metal-free oxidative α-cyanation of N-acyl/sulfonyl 1,2,3,4-tetrahydroisoquinolines (THIQs) has been accomplished at an ambient temperature via DDQ oxidation and subsequent trapping of N-acyl/sulfonyl iminium ions with (n-Bu)3SnCN. Employing readily removable N-acyl/sulfonyl groups as protecting groups rather than N-aryl ones enables a wide range of applications in natural product synthesis. The synthetic utility of the method was illustrated using a short and efficient formal total synthesis of (±)-calycotomine in three steps.


Del.icio.us Digg Facebook Google StumbleUpon Twitter
 
77 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
Molecules, Vol. 23, Pages 3224: Antitumor Effect of n-Butylidenephthalide Encapsulated on B16/F10 Melanoma Cells In Vitro with a Polycationic Liposome Containing PEI and Polyethylene Glycol Complex (Molecules)
Molecules, Vol. 23, Pages 3222: Rapid Characterization and Identification of Chemical Constituents in Gentiana radix before and after Wine-Processed by UHPLC-LTQ-Orbitrap MSn (Molecules)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Molecular Biology

Use these buttons to bookmark us:
Del.icio.us Digg Facebook Google StumbleUpon Twitter


Valid HTML 4.01 Transitional
Copyright © 2008 - 2018 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Travel Photos Nachrichten Indigonet Finances Leer Mandarijn