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RSS FeedsMolecules, Vol. 23, Pages 3216: Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells (Molecules)

 
 

8 december 2018 19:00:24

 
Molecules, Vol. 23, Pages 3216: Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells (Molecules)
 




We have designed and synthesized 6 ent-Kaurane-type diterpenoid derivatives containing ?,?-unsaturated ketone moieties. In vitro, activity was evaluated against three human tumor cell lines and a rat myogenic cell line (HepG2, NSCLC-H292, SNU-1040, L6) by MTT assay. All the tested compounds exhibited comparable or higher activity than DDP and eriocalyxin B. Compounds 16, 17 and 18 are promising anti-tumor leads due to their cytotoxic potencies and higher selectivity, with SI values of 161.06, 47.80 and 128.20, respectively.


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120 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
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