Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions (Cell Chemical Biology)

Chiang et al. identified synthetic molecules that activate human DRV1/GPR32 receptor using high-throughput screening (>48,000 compounds). DRV1/GPR32 and its ligand resolvin D1 display pro-resolving actions in inflammation. These molecules act as resolvin D1 mimetics, offering templates to facilitate therapeutic development targeting DRV1 to promote resolution of inflammation.