Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance (Cell Stem Cell)

Gupta et al. discuss how cells acquire plasticity and the role of plasticity in initiating cancer, cancer progression, and metastasis and in developing therapy resistance. The article also highlights the epithelial-to-mesenchymal transition (EMT) and known molecular mechanisms underlying plasticity, and it considers potential therapeutic avenues.