yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs (Cell Stem Cell)

De novo DNA methylation facilitates the stabilization of cellular identities during embryogenesis, while loci encoding regulators of developmental cell fate decisions remain hypomethylated. Frank et al. reveal a long non-coding-RNA-mediated regulatory layer essential for safeguarding these loci from aberrant DNA methylation.