Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood (Developmental Cell)

Storelli et al. show that the Drosophila HNF4 nuclear receptor couples lipid metabolism with development to meet the needs of adult life. Drosophila HNF4 directs the rapid conversion of lipid stores into waterproofing hydrocarbons at the onset of adulthood, allowing the animal to adapt to dry conditions and dietary sugars.