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RSS FeedsCytochrome P450 1A1 opens up to new substrates [Enzymology] (Journal of Biological Chemistry)

 
 

16 december 2018 08:00:35

 
Cytochrome P450 1A1 opens up to new substrates [Enzymology] (Journal of Biological Chemistry)
 


The cytochromes P450 (CYPs) oxidatively transform a huge number of substrates in both prokaryotic and eukaryotic organisms, but the mechanisms by which they accommodate these diverse molecules remain unclear. A new study by Bart and Scott reports two co-crystal structures of CYP1A1 that reveal structural rearrangements and flexible interaction networks that explain how the active site cavity shapes itself around new ligands. These data open the door to an increased understanding of fundamental enzyme behavior and improved searches for anti-cancer compounds.


 
57 viewsCategory: Biochemistry
 
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A multipronged approach unravels unprecedented protein-protein interactions in the human 2-oxoglutarate dehydrogenase multienzyme complex [Molecular Biophysics] (Journal of Biological Chemistry)
 
 
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