Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability (Molecular Cell)

Meisenberg et al. show that, in response to DNA double strand breaks (DSBs), cohesin is required to repress nearby transcription. This happens throughout interphase, regardless of whether a sister chromatid is present. Failure to repress transcription near a DNA DSB results in an increase in large-scale chromosome rearrangements.