Characterization of MCU-Binding Proteins MCUR1 and CCDC90B -- Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles (Structure)

Performing a bioinformatic analysis, Adlakha et al. identify a family of membrane-bound coiled-coil proteins and solve the structure of the human representative CCDC90A. They build structural models for MCUR1, a regulator of mitochondrial Ca2+ uptake, and bacterial homologs. Finally, they functionally analyze single domains and identify the head as the functional module.