MyJournals Home  

RSS FeedsToxins, Vol. 11, Pages 32: Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms (Toxins)

 
 

10 january 2019 15:00:46

 
Toxins, Vol. 11, Pages 32: Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms (Toxins)
 




The recombinant antibody fragments generated against the toxic components of scorpion venoms are considered a promising alternative for obtaining new antivenoms for therapy. Using directed evolution and site-directed mutagenesis, it was possible to generate a human single-chain antibody fragment with a broad cross-reactivity that retained recognition for its original antigen. This variant is the first antibody fragment that neutralizes the effect of an estimated 13 neurotoxins present in the venom of nine species of Mexican scorpions. This single antibody fragment showed the properties of a polyvalent antivenom. These results represent a significant advance in the development of new antivenoms against scorpion stings, since the number of components would be minimized due to their broad cross-neutralization capacity, while at the same time bypassing animal immunization.


Del.icio.us Digg Facebook Google StumbleUpon Twitter
 
44 viewsCategory: Toxicology
 
Toxins, Vol. 11, Pages 33: Safety of Corn and Corn-Based Products Intended for Human Consumption Concerning Fumonisins from a Brazilian Processing Plant (Toxins)
Toxins, Vol. 11, Pages 31: Assessment of Toxigenic Fusarium Species and Their Mycotoxins in Brewing Barley Grains (Toxins)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Toxicology

Use these buttons to bookmark us:
Del.icio.us Digg Facebook Google StumbleUpon Twitter


Valid HTML 4.01 Transitional
Copyright © 2008 - 2019 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Travel Photos Nachrichten Indigonet Finances Leer Mandarijn