Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy (Immunity)

Since chronic activation promotes terminal T cell differentiation (exhaustion), it has remained unclear how checkpoint blockade mediates a proliferative response of tumor-infiltrating T cells. Siddiqui et al. identify intratumoral, tumor-reactive Tcf1+PD-1+CD8+ T cells that display stem-like properties and that promote tumor control in response to vaccination and checkpoint blockade immunotherapy.