Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability (Molecular Cell)

Replication stress is a hallmark of many cancers. Teloni et al. identify the pre-mRNA cleavage factor WDR33 as regulator of replication stress resilience and demonstrate that, when WDR33 function is impaired, unreleased nascent transcripts and genomic loci re-localize toward the nuclear periphery, where they cause replication stress and DNA damage.