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RSS FeedsMechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a (Molecular Cell)

 
 

11 january 2019 15:00:22

 
Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a (Molecular Cell)
 


Swarts et al. elucidated two structures of Cas12a in complex with a guide RNA and with either single-stranded or double-stranded DNA targets. Together with biochemical assays, these structures reveal the mechanisms of Cas12a-mediated cis and trans cleavage of DNA substrates.


 
71 viewsCategory: Molecular Biology, Cell Biology
 
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