Dynamics of Free and Chromatin-Bound Histone H3 during Early Embryogenesis (Current Biology)

Shindo and Amodeo examine the nuclear trafficking and chromatin dynamics of histone H3 during early embryogenesis in Drosophila. In the early cell cycles, large pools of free H3 accumulate in the nucleus. These pools become depleted in later cycles with a corresponding reduction of H3 on chromatin. The H3.3 variant ultimately replaces H3 on chromatin.