Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits (Cell Metabolism)

Norheim and colleagues use the hybrid mouse diversity panel to comprehensively address the role of sex, and its interaction with genetic background, on cardio-metabolic phenotypes and gene expression. They discover a sex-specific obesity locus for Lyplal1, reveal sex-specific regulation of adipose tissue beiging, and find gene-by-sex interactions for mitochondrial function.