The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging (Molecular Cell)

Aging leads to alterations in several key biological processes. However, whether and how these age-associated dysfunctions are interconnected is still poorly understood. Here, D`Amico et al. discovered that the RNA-binding protein PUM2 is induced upon aging and links impaired protein homeostasis and mitochondrial dysfunction, two well-known hallmarks of aging.