Muscle Stem Cells Give Rise to Rhabdomyosarcomas in a Severe Mouse Model of Duchenne Muscular Dystrophy (Cell Reports)

Boscolo Sesillo et al. describe how Duchenne muscular dystrophy severity increases rhabdomyosarcoma (RMS) formation and reduces latency. This study shows that muscle stem cells give rise to tumorspheres in vitro and RMS tumors in vivo and identify genes involved in RMS growth.