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16 january 2019 04:00:05

 
Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia (Cell Reports)
 


Paonessa et al. show that mutations in the gene encoding the microtubule-associated protein tau that cause frontotemporal dementia result in microtubule-mediated deformation of the neuronal nucleus and disrupted nucleocytoplasmic transport. These data indicate that perturbed nucleocytoplasmic transport is a pathogenic mechanism in multiple forms of neurodegenerative disease.


 
122 viewsCategory: Cell Biology
 
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