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RSS FeedsThe Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling (Cell Reports)

 
 

16 january 2019 04:00:05

 
The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling (Cell Reports)
 


SJ assembly is a hallmark of EC differentiation in the Drosophila midgut. Xu et al. identify SJ proteins as potent tumor suppressors and uncover Hippo signaling as the surveillance mechanism for SJ deficiency. Specifically, they demonstrate that SJ protein Tsp2A facilitates the endocytic degradation of the Hippo-pathway-antagonizing molecule aPKC.


 
137 viewsCategory: Cell Biology
 
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