A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs (Cell Reports)

Garcia-Muse et al. show that the checkpoint kinases ATM and ATR respond to excessive or unrepaired meiotic DSBs by phosphorylating the core synaptonemal complex, which channels repair via the sister chromatid. These findings reveal a mechanism that switches repair partner bias to protect meiotic cells from unscheduled DNA breaks.