Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis (Cell Reports)

Koliaraki et al. show that MyD88 in mesenchymal cells is responsible for its tumor-promoting role in the Apcmin/+ model. They further show that this is a TLR4-mediated mechanism that leads to the production of pro-tumorigenic molecules, also identified in human CAFs.