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RSS FeedsAutoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging (Cell Metabolism)

 
 

17 january 2019 17:00:06

 
Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging (Cell Metabolism)
 


Menopause is associated with bone loss. Hayashi et al. show that estrogen induces expression of the osteoprotective protein semaphorin 3A (Sema3A), which acts on osteocytes to promote their survival and maintain bone homeostasis. An activator of soluble guanylate cyclase-cGMP signaling mimicked Sema3A action and ameliorated bone loss after ovariectomy.


 
87 viewsCategory: Cell Biology
 
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