Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow (Cell Stem Cell)

Bone marrow hematopoietic stem cells reside in perivascular niches associated with sinusoids and require factors from leptin receptor+ stromal cells and endothelial cells. Morrison and colleagues show that c-kit+-restricted hematopoietic progenitors also require Stem Cell Factor made by LepR+ cells, but not endothelial cells. At least some of these restricted progenitors reside in perisinusoidal niches.